Significantly low lymphocytosis, high levels of immunoglobulin G in the peripheral blood, and high values of the leukocyte intoxication index were also characteristic for patients with paracancic complications compared with patients without paranormal inflammatory changes .
A paracancic infection has a significant effect on the structure and properties of red blood cells and platelets. The aggregation properties of erythrocytes were investigated by microscopying their suspension in their own
platelet-free plasma at a dilution of 1: 400c by calculating the degree of aggregation, the number of non-aggregated erythrocytes, the average number of cells in one aggregate, and the percentage of combined erythrocytes .
To assess platelet hemostasis, the total number of platelets was determined in the Goryaev chamber by the COLIPC method, the content of acid phosphotase in platelets (as a marker of lysosomal membranes) —by the method , glycogen content — by the method . Platelet aggregation after induction with adenosine diphosphate at a final concentration of 3 . 10 – M were recorded using a photoelectrometric agregograph, the measuring part of which was the FEK-56 M photoelectric colorimeter, which recorded the laboratory compensatory two-coordinate self-recording instrument LCD-4 . As the most informative indicators of platelet aggregatogram selected: the rate of aggregation, as well as the rate and relative degree of disaggregation of blood platelets.
From the presented it is clear that lung cancer in the advanced stages of the disease proceeds against the background of hyperagregation of erythrocytes and platelets, which was expressed in increased aggregation activity of red blood cells, reduction of their suspension stability, thrombocytosis, destruction of lysosomal membranes and energy hungry platelets, their tendency to slow down the platelets, their tendency to slow down the platelets. little reversible aggregation. In patients with paracancic inflammatory changes, these hematological disorders were more pronounced than in patients with uncomplicated forms of lung cancer.
Thus, the presented data show that patients with advanced stages of lung cancer develop pronounced pathological disorders in the functioning of many vital systems of the body: cardiovascular, respiratory, blood formation, significant changes in plasma and cell hemostasis occur, and the immunological tolerance of the body decreases. The most significant disorders develop in the event of paracancrosis inflammatory changes in the lungs and surrounding tissues. In such a situation, functional studies performed in a rotary manner make it possible to evaluate not only the patient’s condition, but also to determine the effectiveness of preoperative preparation and promptly change its content.
Nevertheless, even with the use of the whole complex of functional research methods, it is impossible to evaluate the functional operability of lung cancer patients. First, all methods of functional research assess the state of individual organs or functional systems, but not of the organism as a whole, and it is at the level of the whole organism that the person adapts to the new, related to the operation, living conditions. In addition, during the preoperative period, studies are performed under conditions of relative rest, i.e. in the state to which the patient’s body has in most cases already adapted.
Therefore, the survey program must necessarily include stress tests. Only by determining the patient’s response to the standard load and thereby evaluating the patient’s adparation reserves, can one predict his response to surgery.